m-Chloroperbenzoic acid → Benzhydryl 3-fluoromethyl-7-(2-thienylacetamido)-3-cephem-4-carboxylate-1-oxide

Participants

Reaction Steps

To a solution of 1.04 g of benzhydryl 3-fluoromethyl-7-(2-thienylacetamido)-2-cephem-4-carboxylate in 10 ml of CHCl3 at 0° is added dropwise a solution of 0.35 g of m-chloroperbenzoic acid in 5 ml of CHCl3. The solution is stirred at 0° for 2.5 hours, then diluted with CHCl3 and washed with NaHCO 3, the dried (MgSO4) and evaporated in vacuo. The residue is recrystallized from methanol to yield benzhydryl 3-fluoromethyl-7-(2-thienylacetamido)-3-cephem-4-carboxylate-1-oxide.

Provenance & Evidence