HRID1605402

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID70297

Benzenecarboperoxoic acid, 3-chloro-

C7H5ClO3

结构：O=C(Cc1cccs1)NC1C(=O)N2C(C(=O)OC(c3ccccc3)c3ccccc3)C(CF)=CS[C@H]12

HCID68132614

未命名化合物

PRODUCTS

生成物

结构：O=C(Cc1cccs1)NC1C(=O)N2C(C(=O)OC(c3ccccc3)c3ccccc3)=C(CF)CS(=O)[C@H]12

HCID68131350

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID6212

Chloroform

CHCl3

3 次

PROCEDURE

实验过程

To a solution of 1.04 g of benzhydryl 3-fluoromethyl-7-(2-thienylacetamido)-2-cephem-4-carboxylate in 10 ml of CHCl3 at 0° is added dropwise a solution of 0.35 g of m-chloroperbenzoic acid in 5 ml of CHCl3. The solution is stirred at 0° for 2.5 hours, then diluted with CHCl3 and washed with NaHCO 3, the dried (MgSO4) and evaporated in vacuo. The residue is recrystallized from methanol to yield benzhydryl 3-fluoromethyl-7-(2-thienylacetamido)-3-cephem-4-carboxylate-1-oxide.

WORKUP

后处理

washwashed with NaHCO 3
dry with materialthe dried (MgSO4)
customevaporated in vacuo
customThe residue is recrystallized from methanol

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-90a932f6b1114379af9a97dd68aae9b4
来源数据集: uspto-grants-1976_04
DOI: 10.6084/m9.figshare.5104873.v1
专利: US03950329
来源说明: uspto-grants-1976_04

反应 SMILES

[F:1][CH2:2][C:3]1[CH:8]([C:9]([O:11][CH:12]([C:19]2[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=2)[C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)=[O:10])[N:7]2[C:25](=[O:36])[CH:26]([NH:27][C:28](=[O:35])[CH2:29][C:30]3[S:31][CH:32]=[CH:33][CH:34]=3)[C@H:6]2[S:5][CH:4]=1.ClC1C=CC=C(C(OO)=[O:45])C=1>C(Cl)(Cl)Cl>[F:1][CH2:2][C:3]1[CH2:4][S:5](=[O:45])[C@@H:6]2[CH:26]([NH:27][C:28](=[O:35])[CH2:29][C:30]3[S:31][CH:32]=[CH:33][CH:34]=3)[C:25](=[O:36])[N:7]2[C:8]=1[C:9]([O:11][CH:12]([C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1)[C:13]1[CH:14]=[CH:15][CH:16]=[CH:17][CH:18]=1)=[O:10]