Hydrogen Bromide → 1,4-Dimethyl-2-[(2-aminoethyl)thiomethyl]imidazole dihydrobromide

HRID 1605420Notes

Reaction equation

[CH3:1][N:2]1[CH:6]=[C:5]([CH3:7])[N:4]=[C:3]1[CH2:8]O.Cl.[NH2:11][CH2:12][CH2:13][SH:14].C(O)(C)C.CO.[BrH:21]>>[BrH:21].[BrH:21].[CH3:1][N:2]1[CH:6]=[C:5]([CH3:7])[N:4]=[C:3]1[CH2:8][S:14][CH2:13][CH2:12][NH2:11]

Participants

Reactant 4

HCID 260Hydrogen Bromide

HCID 9082Cysteamine Hydrochloride

HCID 12923402(1,4-dimethyl-1H-imidazol-2-yl)methanol

HCID 21255859Isopropanol methanol

Product 1

HCID 205579691,4-Dimethyl-2-[(2-aminoethyl)thiomethyl]imidazole dihydrobromide

Procedure

The reaction of 1,4-dimethyl-2-hydroxymethylimidazole (2.5 g.) with cysteamine hydrochloride (2.5 g.) in aqueous hydrobromic acid by the method described in Example 1 (i) (a) gave 1,4-dimethyl-2[(2-aminoethyl)thiomethyl]imidazole dihydrobromide (6.2 g), m.p. 161°-163° (from isopropyl alcohol-methanol).

Sources & evidence

ORD record: ord-3ffa7d8be8a64822aab874adc289a444
Source dataset: uspto-grants-1976_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US03950353

Reaction notes

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