Thionyl Chloride → 3-(2-Hydroxyethoxymethyl)pyrazole

HRID 1605426Notes

Reaction equation

HRID 1605426 reaction equation
Cl[CH2:2][C:3]1[CH:7]=[CH:6][NH:5][N:4]=1.[OH:8][C:9]1[C:13](C)=CNN=1.S(Cl)(Cl)=[O:16].[Na]>C(O)CO>[OH:8][CH2:9][CH2:13][O:16][CH2:2][C:3]1[CH:7]=[CH:6][NH:5][N:4]=1

Participants

6

Reactant 4

HCID 24386Thionyl ChlorideHCID 5360545SodiumHCID 178430917HCID 178430917, compoundHCID 178478439HCID 178478439, compound

Product 1

HCID 1785214303-(2-Hydroxyethoxymethyl)pyrazole

Reagents, catalysts & solvents 1

HCID 174Ethylene GlycolSolvent

Procedure

3-Chloromethylpyrazole, prepared by reacting 3-hydroxy-methylpyrazole with thionyl chloride, is reacted with the sodium salt of ethylene glycol to give 3-(2-hydroxyethoxymethyl)-pyrazole. Treatment of 3-(2-hydroxyethoxymethyl)pyrazole with thionyl chloride gives 3 -(2-chloroethoxymethylpyrazole.

Sources & evidence

ORD record
ord-8a0dd4fc650249eb84e985046d4b9b2c
Source dataset
uspto-grants-1976_04
Patent number
US03950353

Reaction notes

Loading…