Hydrogen Bromide → 5-((2-Aminoethyl)thiomethyl)thiazole dihydrobromide

HRID 1605453Notes

Reaction equation

O[CH2:2][C:3]1[S:7][CH:6]=[N:5][CH:4]=1.Cl.[NH2:9][CH2:10][CH2:11][SH:12].CO.[BrH:15]>>[BrH:15].[BrH:15].[NH2:9][CH2:10][CH2:11][S:12][CH2:2][C:3]1[S:7][CH:6]=[N:5][CH:4]=1

Participants

Reactant 4

HCID 260Hydrogen Bromide

HCID 887Methanol

HCID 9082Cysteamine Hydrochloride

HCID 27632165-Thiazolylmethanol

Product 1

HCID 205578455-((2-Aminoethyl)thiomethyl)thiazole dihydrobromide

Procedure

The reaction of 5-hydroxymethylthiazole (2.01 g.) with cysteamine hydrochloride (1.99 g.) in aqueous hydrobromic acid by the method described in Example 1(i)(a) gave 5-[(2-aminoethyl)thiomethyl]thiazole dihydrobromide (4.85 g.), m.p. 191°-194° (from methanol).

Sources & evidence

ORD record: ord-9a881725919d47cb9cdd686c11a8e46f
Source dataset: uspto-grants-1976_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US03950353

Reaction notes

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