Thiophenol → HCID 21520083, compound

HRID 1605508Notes

Reaction equation

HRID 1605508 reaction equation
[CH2:1]([S:8][C:9]1[CH:10]=[C:11]([CH:17]=[C:18]([S:21](=[O:24])(=[O:23])[NH2:22])[C:19]=1Cl)[C:12]([O:14][CH2:15][CH3:16])=[O:13])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[C:25]1([SH:31])[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=1.C1([S-])C=CC=CC=1.[Na+]>C(O)C>[CH2:1]([S:8][C:9]1[CH:10]=[C:11]([CH:17]=[C:18]([S:21](=[O:24])(=[O:23])[NH2:22])[C:19]=1[S:31][C:25]1[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=1)[C:12]([O:14][CH2:15][CH3:16])=[O:13])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

5

Reactant 3

HCID 7969ThiophenolHCID 4110039Sodium benzenethiolateHCID 21520055HCID 21520055, compound

Product 1

HCID 21520083HCID 21520083, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A mixture of ethyl 3-benzylthio-4-chloro-5-sulfamylbenzoate (0.77 g), thiophenol (0.36 ml), and dry ethanol (15 ml) containing 3 millimoles of sodium thiophenolate is refluxed for 20 hours. After cooling the precipitate is collected by filtration to yield ethyl 3-benzylthio-4-phenylthio-5-sulfamylbenzoate with a melting point of 151°- 152° C.

Workup

  1. temperatureis refluxed for 20 hours
  2. temperatureAfter cooling the precipitate
  3. filtrationis collected by filtration

Sources & evidence

ORD record
ord-fd64652a6e134f27affb7e6007f9ff31
Source dataset
uspto-grants-1976_04
Patent number
US03950376

Reaction notes

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