Acetic Acid → HCID 21520118, compound

HRID 1605510Notes

Reaction equation

HRID 1605510 reaction equation
[CH2:1]([S:8][C:9]1[CH:10]=[C:11]([CH:15]=[C:16]([S:19](=[O:22])(=[O:21])[NH2:20])[C:17]=1[Cl:18])[C:12]([OH:14])=[O:13])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.C(O)(=[O:25])C.OO.[OH2:29]>>[CH2:1]([S:8]([C:9]1[CH:10]=[C:11]([CH:15]=[C:16]([S:19](=[O:22])(=[O:21])[NH2:20])[C:17]=1[Cl:18])[C:12]([OH:14])=[O:13])(=[O:25])=[O:29])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

5

Reactant 4

HCID 176Acetic AcidHCID 784Hydrogen PeroxideHCID 962Water2×HCID 21520084HCID 21520084, compound

Product 1

HCID 21520118HCID 21520118, compound

Procedure

A mixture of 3-benzylthio-4-chloro-5-sulfamylbenzoic acid (0.75 g), acetic acid (25 ml), and hydrogen peroxide (2 ml of an 30% aqueous solution) is stirred for 2 days at room temperature. Addition of water (100 ml) precipitates 3-benzylsulfonyl-4-chloro-5-sulfamylbenzoic acid. After collection by filtration and recrystallization from aqueous ethanol the compound crystallizing with one mole of water, is obtained with a melting point of 236° - 237° C.

Workup

  1. customprecipitates 3-benzylsulfonyl-4-chloro-5-sulfamylbenzoic acid
  2. customAfter collection
  3. filtrationby filtration and recrystallization from aqueous ethanol the compound
  4. customis obtained with a melting point of 236° - 237° C.

Sources & evidence

ORD record
ord-9c294eaf5b884d32b893ec76c2923d11
Source dataset
uspto-grants-1976_04
Patent number
US03950376

Reaction notes

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