HCID 178418361, compound → HCID 178511262, compound

HRID 1605535Notes

Reaction equation

HRID 1605535 reaction equation
[C:1]([C@H:3]1[CH2:8][CH2:7][C@H:6]([C:9]([OH:11])=[O:10])[CH2:5][CH2:4]1)#[N:2].[H][H]>CO.[Pd].C>[NH2:2][CH2:1][C@H:3]1[CH2:4][CH2:5][C@H:6]([C:9]([OH:11])=[O:10])[CH2:7][CH2:8]1

Participants

5

Reactant 2

HCID 178418361HCID 178418361, compound2×HCID 178511260HCID 178511260, compound

Product 1

HCID 178511262HCID 178511262, compound

Reagents, catalysts & solvents 2

HCID 14818447PalladiumcarbonCatalystHCID 887MethanolSolvent

Procedure

5 g. of trans-4-cyanocyclohexane-1-carboxylic acid was dissolved in 130 ml of methanol. To this solution, 5 g. of 10 % Pd-charcoal was added and the mixture was shaken in an atmosphere of hydrogen under a normal pressure for about 8 hours until 0.066 mole of hydrogen was absorbed. The reaction product was treated as described in Example 1, and 3.5 g. of trans-4-aminomethylcyclohexane-1-carboxylic acid was obtained.

Workup

  1. customwas absorbed
  2. additionThe reaction product was treated

Sources & evidence

ORD record
ord-4c92b078014e46dc9491e212fc982688
Source dataset
uspto-grants-1976_04
Patent number
US03950405

Reaction notes

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