反应详情

To a stirred suspension of methyl 3,5-dinitro-4-phenylbenzoate (145 g) in 2-methoxyethanol (1.5 l), 2 N sodium hydroxide (300 ml) is added dropwise during about 30 minutes. After additional stirring for about 15 minutes, the resulting solution is acidified by the dropwise addition of 4 N hydrochloric acid (250 ml), and the mixture is thereafter diluted with water (about 3 l). After cooling, the resulting precipitate is collected by filtration, washed with water and dried. After recrystallization from aqueous ethanol, 3,5-dinitro-4-phenylbenzoic acid is obtained with a melting point of 219°-221° C.

1. additionis added dropwise during about 30 minutes
2. temperatureAfter cooling
3. filtrationthe resulting precipitate is collected by filtration
4. washwashed with water
5. customdried
6. customAfter recrystallization from aqueous ethanol