反应详情

A mixture of 3-hydroxy-5-nitro-4-phenylbenzoic acid (3.0 g), benzylbromide (1.5 ml) and 1 N sodium hydroxide (30 ml) is stirred at room temperature for 6-7 hours. After cooling, the precipitated sodium 3-benzyloxy-5-nitro-4-phenylbenzoate is collected by filtration and washed with a small amount of icecold water. After drying, the sodium salt is dissolved in hot water (100 ml), and the 3-benzyloxy-5-nitro-4-phenylbenzoic acid is precipitated by addition of 4 N hydrochloric acid (10 ml). After cooling, the acid is collected by filtration, washed with water and dried. After recrystallization twice from isopropanol, it is obtained with a melting point of 188.5°-189.5° C.

1. temperatureAfter cooling
2. filtrationthe precipitated sodium 3-benzyloxy-5-nitro-4-phenylbenzoate is collected by filtration
3. washwashed with a small amount of icecold water
4. customAfter drying
5. dissolutionthe sodium salt is dissolved in hot water (100 ml)
6. customthe 3-benzyloxy-5-nitro-4-phenylbenzoic acid is precipitated by addition of 4 N hydrochloric acid (10 ml)
7. temperatureAfter cooling
8. filtrationthe acid is collected by filtration
9. washwashed with water
10. customdried
11. customAfter recrystallization twice from isopropanol
12. customit is obtained with a melting point of 188.5°-189.5° C.