3-Benzyloxy-5-nitro-4-phenylbenzoic acid → 5-Amino-3-isopentylthio-4-phenylbenzoic acid

HRID 1605566Notes

Reaction equation

HRID 1605566 reaction equation
C(OC1C=C(C=C([N+]([O-])=O)C=1C1C=CC=CC=1)C(O)=O)C1C=CC=CC=1.[CH2:27]([S:32][C:33]1[CH:34]=[C:35]([CH:39]=[C:40]([N+:48]([O-])=O)[C:41]=1[C:42]1[CH:47]=[CH:46][CH:45]=[CH:44][CH:43]=1)[C:36]([OH:38])=[O:37])[CH2:28][CH:29]([CH3:31])[CH3:30]>>[NH2:48][C:40]1[C:41]([C:42]2[CH:43]=[CH:44][CH:45]=[CH:46][CH:47]=2)=[C:33]([S:32][CH2:27][CH2:28][CH:29]([CH3:31])[CH3:30])[CH:34]=[C:35]([CH:39]=1)[C:36]([OH:38])=[O:37]

Participants

3

Reactant 2

HCID 215468443-Benzyloxy-5-nitro-4-phenylbenzoic acidHCID 215468493-Isopentylthio-5-nitro-4-phenylbenzoic acid

Product 1

HCID 215468865-Amino-3-isopentylthio-4-phenylbenzoic acid

Procedure

By replacing in Example 2, step D, 3-benzyloxy-5-nitro-4-phenylbenzoic acid with 3-isopentylthio-5-nitro-4-phenylbenzoic acid, and following the procedure described, 5-amino-3-isopentylthio-4-phenylbenzoic acid is obtained crystallizing with 0.25 mole of water with a melting point of 124.5°-125.5° C.

Sources & evidence

ORD record
ord-54b8142f2a1b4d4aa86c3dbeb1b51fef
Source dataset
uspto-grants-1976_04
Patent number
US03950380

Reaction notes

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