1-(4-Cyclohexylphenyl)ethan-1-one → (E)-4-(4-cyclohexyl-phenyl)-3-pentene-2-one

Participants

Reaction Steps

(E)-4-(4-cyclohexyl-phenyl)-3-pentene-2-one was prepared analogous to Example 52 from 4'-cyclohexyl-acetophenone and ethyl (E)-3-ethoxy-crotonate with a yield of 55% of theory. B.p. 148°-151°C at 0.4 mm Hg; m.p. 49°-50°C (after recrystallization from methanol and petroleum ether). Characteristic signals in NMR (CDCl3): τ 3.50 (1H-q; /J/=1.2 ± 0.1 Hz); τ 7.50 (3H-d; /J/=1.2 ± 0.1 Hz).

Provenance & Evidence