反应详情

4-Hydroxy-6-phenylpyrimidine (2.1 g.) is added to phosphorous oxychloride (60 ml.) and refluxed for 1.5 hours. Excess phosphorous oxychloride is removed in vacuo, and the dark oil poured over concentrated ammonium hydroxide/ice. The precipitate which forms is filtered, washed with water and dried, 2.1 g., m.p. 95°-98° C.

1. temperaturerefluxed for 1.5 hours
2. customExcess phosphorous oxychloride is removed in vacuo
3. additionthe dark oil poured over concentrated ammonium hydroxide/ice
4. filtrationThe precipitate which forms is filtered
5. washwashed with water
6. customdried