反应详情

A mixture of 5 g of 2,5-dimethyl-4-hydroxy-3-(2H)-furanone and 10.6 g of benzaldehyde was added to a mixture of 20 ml of water, 20 ml of dioxan and 0.5 g of oxalic acid. The mixture was then refluxed for 4 hours, cooled and extracted with chloroform. The chloroform extract was evaporated and the residue purified by column chromatography over polyamide using ether - light petroleum 50/50 as the eluent; 2.7 g (30% yield) of the title compound was obtained which was recrystallized from chloroform, m.p. = 122°-124°C.

1. temperatureThe mixture was then refluxed for 4 hours
2. temperaturecooled
3. extractionextracted with chloroform
4. extractionThe chloroform extract
5. customwas evaporated
6. customthe residue purified by column chromatography over polyamide