p-Toluenesulfonic acid → HCID 86733245, compound

HRID 1605827Notes

Reaction equation

HRID 1605827 reaction equation
[Cl:1][CH2:2][O:3][C:4](=[O:26])[CH2:5][NH:6]C(C1C=CC=CC=1)(C1C=CC=CC=1)C1C=CC=CC=1.[C:27]1([CH3:37])[CH:32]=[CH:31][C:30]([S:33]([OH:36])(=[O:35])=[O:34])=[CH:29][CH:28]=1>CC(C)=O>[C:27]1([CH3:37])[CH:28]=[CH:29][C:30]([S:33]([OH:36])(=[O:34])=[O:35])=[CH:31][CH:32]=1.[Cl:1][CH2:2][O:3][C:4](=[O:26])[CH2:5][NH2:6]

Participants

4

Reactant 2

HCID 6101p-Toluenesulfonic acidHCID 21545310HCID 21545310, compound

Product 1

HCID 86733245HCID 86733245, compound

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent2×

Procedure

3.5 g of N-tritylglycine chloromethyl ester in acetone (25 ml) were treated with p-toluenesulphonic acid (1.9 g) in acetone (25 ml). After standing for one-half hour at room temperature, the resulting precipitate was collected on a filter. The product thus obtained had a melting point of 188°-190°C.

Workup

  1. waitAfter standing for one-half hour at room temperature
  2. customthe resulting precipitate was collected on a filter
  3. customThe product thus obtained

Sources & evidence

ORD record
ord-f08d7a80791d47089ccdc950e1344392
Source dataset
uspto-grants-1976_04
Patent number
US03951957

Reaction notes

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