Acetyl chloride → HCID 21518736, compound

HRID 1605843Notes

Reaction equation

HRID 1605843 reaction equation
[CH:1]([N:4]1[C:9](=[O:10])[N:8]=[C:7]([S:11][CH3:12])[NH:6][C:5]1=[O:13])([CH3:3])[CH3:2].[Na].[C:15](Cl)(=[O:17])[CH3:16]>O1CCCC1>[C:15]([N:8]1[C:7]([S:11][CH3:12])=[N:6][C:5](=[O:13])[N:4]([CH:1]([CH3:3])[CH3:2])[C:9]1=[O:10])(=[O:17])[CH3:16]

Participants

4

Reactant 2

HCID 6367Acetyl chlorideHCID 68142954HCID 68142954, compound

Product 1

HCID 21518736HCID 21518736, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

To 9.0 parts sodium 3-isopropyl-6-methylthio-s-triazine-2,4(1H,3H)-dione prepared as in Example 10 in 100 parts tetrahydrofuran can be added 3.1 parts acetyl chloride. The reaction can be refluxed for 5 hours and the solvent evaporated. Methylene chloride can be added to the residue and the solution can be washed with 1N sodium hydroxide and brine. After drying and evaporation of the solvent, the residue can be recrystallized from chlorobutane.

Workup

  1. customThe reaction
  2. temperaturecan be refluxed for 5 hours
  3. customthe solvent evaporated
  4. additionMethylene chloride can be added to the residue
  5. washthe solution can be washed with 1N sodium hydroxide and brine
  6. customAfter drying
  7. customevaporation of the solvent
  8. customthe residue can be recrystallized from chlorobutane

Sources & evidence

ORD record
ord-b03e402f6d3d4a68addb5b9ce28d8fdb
Source dataset
uspto-grants-1976_04
Patent number
US03951971

Reaction notes

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