Hydrochloric Acid → HCID 86733246, compound

HRID 1605847Notes

Reaction equation

HRID 1605847 reaction equation
[ClH:1].[C:2]([CH2:6][CH2:7][C:8]([NH2:10])=[NH:9])([O:4]C)=[O:3].Cl>>[ClH:1].[C:8]([CH2:7][CH2:6][C:2]([OH:4])=[O:3])(=[NH:9])[NH2:10]

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 1230032910567-33-6

Product 1

HCID 86733246HCID 86733246, compoundYield 99%

Procedure

A solution of 7.8 g. (0.047 mole) of β-carbomethoxypropionamidine hydrochloride in 217 ml. of 12N hydrochloric acid is heated at steam bath temperatures for 1 hour. The solution is cooled. evaporated in vacuo to dryness, and the residual product triturated several times with ethylene dichloride and filtered, 7.1 g. (99% yield), m.p. 138°-140° C. (McElvain, et al., J. Am. Chem. Soc., 71, 40 (1949) reports a melting point for crude product of 131°-137° C.).

Workup

  1. temperatureThe solution is cooled
  2. customevaporated in vacuo to dryness
  3. customthe residual product triturated several times with ethylene dichloride
  4. filtrationfiltered
  5. customfor crude product of 131°-137° C.

Sources & evidence

ORD record
ord-1873fea4e61b425db4344d3ceda32bf7
Source dataset
uspto-grants-1976_04
Patent number
US03951952

Reaction notes

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