Sodium Hydroxide → 56915-77-6

HRID 1605924Notes

Reaction equation

HRID 1605924 reaction equation
F[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8](=[O:10])[CH3:9].[CH3:11][N:12]1[CH2:17][CH2:16][NH:15][CH2:14][CH2:13]1.[OH-].[Na+]>O>[CH3:11][N:12]1[CH2:17][CH2:16][N:15]([C:2]2[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=2[C:8](=[O:10])[CH3:9])[CH2:14][CH2:13]1

Participants

5

Reactant 3

HCID 14798Sodium HydroxideHCID 531671-MethylpiperazineHCID 96744o-Fluoroacetophenone

Product 1

HCID 2140456756915-77-6

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

A mixture of 55.2 g. of o-fluoroacetophenone and 100 ml. of N-methyl-piperazine is heated at 95°-100° for 19 hours, then cooled and poured into 1600 ml. of water containing 22 ml. of 50% aqueous sodium hydroxide. The mixture is extracted with three 300 ml. portions of ether. The combined ether extract is washed thoroughly with water, then with saturated aqueous sodium chloride, dried and evaporated to give o-(4-methyl-1-piperazinyl)acetophenone as a viscous oil, suitable for use without further purification.

Workup

  1. additionA mixture of 55.2 g
  2. temperaturecooled
  3. additionpoured into 1600 ml
  4. extractionThe mixture is extracted with three 300 ml
  5. extractionThe combined ether extract
  6. washis washed thoroughly with water
  7. dry with materialwith saturated aqueous sodium chloride, dried
  8. customevaporated

Sources & evidence

ORD record
ord-0ddc891617ce43ada78f6a25d8d44a80
Source dataset
uspto-grants-1976_04
Patent number
US03951982

Reaction notes

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