Benzylamine → HCID 16050313, compound

HRID 1605936Notes

Reaction equation

HRID 1605936 reaction equation
[CH3:1][N:2]1[C@H:6]([C:7]([O:9][CH2:10][CH3:11])=[O:8])[CH2:5][CH2:4][C@@H:3]1[C:12]([O:14]CC)=O.[CH2:17]([NH2:24])[C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1>C1(C)C(C)=CC=CC=1>[CH2:17]([NH:24][C:12]([C@H:3]1[N:2]([CH3:1])[C@@H:6]([C:7]([O:9][CH2:10][CH3:11])=[O:8])[CH2:5][CH2:4]1)=[O:14])[C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1

Participants

4

Reactant 2

HCID 7504BenzylamineHCID 13279466Diethyl (2R,5S)-1-methylpyrrolidine-2,5-dicarboxylate

Product 1

HCID 16050313HCID 16050313, compound

Reagents, catalysts & solvents 1

HCID 7237O-XyleneSolvent

Procedure

A solution of diethyl cis-1-methylpyrrolidine-2,5-dicarboxylate (10.95 g, 0.0478 mole) and benzylamine (5.2 ml, 0.048 mole) in 30 ml xylene was refluxed 72 hours at 140° C. After evaporation of the xylene in vacuo, the oily residue was fractionated on a Vigreux column. After an initial fraction of the starting compound (0.49 g), the product was collected: 7.11 g (boiling point 160° C, 0.25 mm).

Workup

  1. customAfter evaporation of the xylene in vacuo
  2. customAfter an initial fraction of the starting compound (0.49 g), the product was collected

Sources & evidence

ORD record
ord-061882ba694a433d875e7157f10cbd22
Source dataset
uspto-grants-1976_04
Patent number
US03951980

Reaction notes

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