Hydrochloric Acid → HCID 21545623, compound

Participants

Reaction Steps

0.2 G. of 4'-{2-[6-(p-fluorophenyl)-dihydro-6-methyl-2H-1,3-oxazin-3(4H)-yl]ethoxy}acetanilide hydrochloride and 2 ml. of conc. hydrochloric acid are heated on the steam bath for 4 hours. The excess hydrochloric acid is evaporated under reduced pressure and the residue brought to crystallization with ethanol-acetic acid ethyl ester. The p-{2-[4-(p-fluorophenyl)-3,6-dihydro-1(2H)-pyridyl]ethoxy}aniline dihydrochloride hydrate obtained melts at 180°-183°C. after recrystallization from ethanol-acetic acid ethyl ester.

Provenance & Evidence