Hydrochloric Acid → HCID 21545623, compound

HRID 1605956Notes

Reaction equation

HRID 1605956 reaction equation
[ClH:1].[F:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]2([CH3:28])[O:14][CH2:13][N:12]([CH2:15][CH2:16][O:17][C:18]3[CH:27]=[CH:26][C:21]([NH:22]C(=O)C)=[CH:20][CH:19]=3)[CH2:11][CH2:10]2)=[CH:5][CH:4]=1.Cl>>[OH2:14].[ClH:1].[ClH:1].[F:2][C:3]1[CH:4]=[CH:5][C:6]([C:9]2[CH2:10][CH2:11][N:12]([CH2:15][CH2:16][O:17][C:18]3[CH:27]=[CH:26][C:21]([NH2:22])=[CH:20][CH:19]=3)[CH2:13][CH:28]=2)=[CH:7][CH:8]=1

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 21545597HCID 21545597, compound

Product 1

HCID 21545623HCID 21545623, compound

Procedure

0.2 G. of 4'-{2-[6-(p-fluorophenyl)-dihydro-6-methyl-2H-1,3-oxazin-3(4H)-yl]ethoxy}acetanilide hydrochloride and 2 ml. of conc. hydrochloric acid are heated on the steam bath for 4 hours. The excess hydrochloric acid is evaporated under reduced pressure and the residue brought to crystallization with ethanol-acetic acid ethyl ester. The p-{2-[4-(p-fluorophenyl)-3,6-dihydro-1(2H)-pyridyl]ethoxy}aniline dihydrochloride hydrate obtained melts at 180°-183°C. after recrystallization from ethanol-acetic acid ethyl ester.

Workup

  1. customThe excess hydrochloric acid is evaporated under reduced pressure
  2. customthe residue brought to crystallization with ethanol-acetic acid ethyl ester

Sources & evidence

ORD record
ord-0e9ac479b4aa431d865af4eb9395dcc2
Source dataset
uspto-grants-1976_04
Patent number
US03951987

Reaction notes

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