反应详情

1.77 g of 4-(p-fluorophenyl)-1,2,3,6-tetrahydropyridine, 0.8 g. of ethylene chlorohydrin, 1.2 g. of sodium carbonate and a few crystals of sodium iodide are heated under reflux conditions in 10 ml. of ethanol for 24 hours and filtered hot and the filtrate is evaporated to dryness. The residual oil is purified by column chromatography on silica gel with acetic acid ethyl ester-ethanol (1:1) as eluting agent. The 1-(2-hydroxyethyl)-4-(p-fluorophenyl)-1,2,3,6-tetrahydropyridine obtained from the eluate melts at 96°-98°C. after recrystallization from cyclohexane.

1. filtrationfiltered hot
2. customthe filtrate is evaporated to dryness
3. customThe residual oil is purified by column chromatography on silica gel with acetic acid ethyl ester-ethanol (1:1)
4. washas eluting agent