反应详情

Nicotinic acid (0.5 mole), diethylamine (0.5 mole), toluene (35 ml), n-butanol (60 ml) and tetra n-butoxy titanium were heated until all water was removed by azeotropic distillation from the reaction mixture. The volatile solvents were then distilled off and the remaining product fractionally distilled under vacuum to give nikethamide identified both by its boiling point and its infra-red spectrum.

1. customwas removed by azeotropic distillation from the reaction mixture
2. distillationThe volatile solvents were then distilled off
3. distillationthe remaining product fractionally distilled under vacuum