Ethanol → HCID 54301143, compound

HRID 1605978Notes

Reaction equation

HRID 1605978 reaction equation
C(OC(=O)C[C:6]([CH:8]=[CH:9][C:10]1[CH:15]=[CH:14][CH:13]=[C:12]([N+:16]([O-:18])=[O:17])[CH:11]=1)=[O:7])C.[C:20]([CH:23]=[C:24]1[CH2:28][CH2:27][CH2:26][NH:25]1)(=[O:22])[CH3:21].[CH:29]([OH:32])(C)[CH3:30].[CH2:33](O)[CH3:34]>>[CH2:29]([O:32][C:6]([C:8]1[CH:9]([C:10]2[CH:15]=[CH:14][CH:13]=[C:12]([N+:16]([O-:18])=[O:17])[CH:11]=2)[C:23]([C:20](=[O:22])[CH3:21])=[C:24]2[N:25]([CH2:26][CH2:27][CH2:28]2)[C:33]=1[CH3:34])=[O:7])[CH3:30]

Participants

5

Reactant 4

HCID 702EthanolHCID 3776IsopropanolHCID 53828414HCID 53828414, compoundHCID 692457831-(Pyrrolidin-2-ylidene)propan-2-one

Product 1

HCID 54301143HCID 54301143, compoundYield 72%

Procedure

Boiling a solution of 8.8 g of 3-nitrobenzylideneacetoacetic acid ethyl ester and 4.6 g of 2-acetylmethylidenepyrrolidine in 50 ml of ethanol for 6 hours yields 5-methyl-7-(3-nitrophenyl)-8-acetyl-1,2,3,7-tetrahydroindolizine-6-carboxylic acid ethyl ester of melting point 161° (isopropanol).

Workup

  1. customfor 6 hours

Sources & evidence

ORD record
ord-f861b06016954684af81bbde45b5b1d7
Source dataset
uspto-grants-1976_04
Patent number
US03951988

Reaction notes

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