o-Fluorobenzaldehyde → HCID 54216523, compound

HRID 1605989Notes

Reaction equation

HRID 1605989 reaction equation
[F:1][C:2]1[CH:9]=[CH:8][CH:7]=[CH:6][C:3]=1[CH:4]=O.[CH3:10][O:11][C:12](=[O:19])[CH:13]=[C:14]([NH2:18])[O:15][CH2:16][CH3:17]>C(O)(C)C>[CH3:10][O:11][C:12]([C:13]1[CH:4]([C:3]2[CH:6]=[CH:7][CH:8]=[CH:9][C:2]=2[F:1])[CH:13]([C:12]([O:11][CH3:10])=[O:19])[C:14]([O:15][CH2:16][CH3:17])=[N:18][C:14]=1[NH2:18])=[O:19]

Participants

4

Reactant 2

HCID 67970o-FluorobenzaldehydeHCID 71366473Methyl 3-amino-3-ethoxyprop-2-enoate

Product 1

HCID 54216523HCID 54216523, compound

Reagents, catalysts & solvents 1

HCID 3776IsopropanolSolvent2×

Procedure

Heating a solution of 6.3 g of 2-fluorobenzaldehyde and 14.5 g of 3-amino-3-ethoxyacrylic acid methyl ester in 50 ml isopropanol for 8 hours yields 2-amino-4-(2-fluorophenyl)-6-ethoxy-4,5-dihydropyridine-3,5-dicarboxylic acid dimethyl ester of melting point 180°C (isopropanol).

Sources & evidence

ORD record
ord-55ebb414ed684e8cb1dbe6caa1e84e64
Source dataset
uspto-grants-1976_04
Patent number
US03951993

Reaction notes

Loading…