HCID 21545736, compound → HCID 21545727, compound

HRID 1606002Notes

Reaction equation

HRID 1606002 reaction equation
[Cl:1][C:2]1[C:10](=[O:11])[C:9]2[N:8]([CH3:12])[N:7]=[CH:6][C:5]=2[C:4](=[O:13])[C:3]=1[NH:14][CH3:15].[N:16]([O-])=[O:17].[Na+]>Cl.O>[Cl:1][C:2]1[C:10](=[O:11])[C:9]2[N:8]([CH3:12])[N:7]=[CH:6][C:5]=2[C:4](=[O:13])[C:3]=1[N:14]([N:16]=[O:17])[CH3:15]

Participants

5

Reactant 2

HCID 21545736HCID 21545736, compoundHCID 23668193Sodium Nitrite

Product 1

HCID 21545727HCID 21545727, compound

Reagents, catalysts & solvents 2

HCID 313Hydrochloric AcidSolventHCID 962WaterSolvent

Procedure

6-Chloro-5-methylamino-1-methylindazole-4,7-dione (4.5 grams) in 30 % hydrochloric acid (50 milliliters was stirred at 0° C and treated dropwise with a solution of sodium nitrite (3.0 grams) in water (20 milliliters). After 1 hour the orange solid which had separated out was collected, washed with water and dried over silica gel to yield the desired product having a melting point of 124°-125° C (with decomposition).

Workup

  1. customAfter 1 hour the orange solid which had separated out
  2. customwas collected
  3. washwashed with water
  4. customdried over silica gel

Sources & evidence

ORD record
ord-e595786a6fef4d33b063a861dce65199
Source dataset
uspto-grants-1976_04
Patent number
US03952003

Reaction notes

Loading…