Benzoyl Peroxide → HCID 12562677, compound

HRID 1606010Notes

Reaction equation

HRID 1606010 reaction equation
[Br:1]N1C(=O)CCC1=O.[CH3:9][C:10]1[CH:11]=[CH:12][C:13]2[O:17][N:16]=[C:15]([C:18]3[CH:23]=[CH:22][C:21]([Cl:24])=[CH:20][CH:19]=3)[C:14]=2[CH:25]=1.C(OOC(=O)C1C=CC=CC=1)(=O)C1C=CC=CC=1>C(Cl)(Cl)(Cl)Cl>[Br:1][CH2:9][C:10]1[CH:11]=[CH:12][C:13]2[O:17][N:16]=[C:15]([C:18]3[CH:23]=[CH:22][C:21]([Cl:24])=[CH:20][CH:19]=3)[C:14]=2[CH:25]=1

Participants

5

Reactant 3

HCID 7187Benzoyl PeroxideHCID 67184N-bromobutanimideHCID 12562671HCID 12562671, compound

Product 1

HCID 12562677HCID 12562677, compound

Reagents, catalysts & solvents 1

HCID 5943Carbon TetrachlorideSolvent

Procedure

N-Bromosuccinimide (26 g.) was added to a cold solution of 5-methyl-3-(4-chlorophenyl)-1,2-benzisoxazole (35 g.) in carbon tetrachloride (250 ml.). Benzoyl peroxide (500 mg.) was added and the mixture was heated under reflux for 3 hours in the presence of U.V. light. The solid residue was filtered off, and the filtrate was evaporated to give 5-bromomethyl-3-(4-chlorophenyl)-1,2-benzisoxazole (m.p. 142°C.).

Workup

  1. temperaturethe mixture was heated
  2. temperatureunder reflux for 3 hours in the presence of U.V
  3. filtrationThe solid residue was filtered off
  4. customthe filtrate was evaporated

Sources & evidence

ORD record
ord-c1206ebd66154e15a7e23db6752278b5
Source dataset
uspto-grants-1976_04
Patent number
US03951999

Reaction notes

Loading…