Sodium Cyanide → HCID 12562683, compound

Participants

Reaction Steps

A mixture of 5-bromomethyl-3-(4-chlorophenyl)-1,2-benzisoxazole (45 g.) and sodium cyanide (7.4 g.) in dry dimethylformamide (800 ml.) was heated on a steam bath for 3 hours. The mixture was filtered and the filtrate was evaporated to dryness, to give 3-(4-chlorophenyl)-1,2-benzisoxazol-5-ylacetonitrile (m.p. 118°C.).

Provenance & Evidence