Sodium Cyanide → HCID 12562683, compound

HRID 1606011Notes

Reaction equation

HRID 1606011 reaction equation
Br[CH2:2][C:3]1[CH:4]=[CH:5][C:6]2[O:10][N:9]=[C:8]([C:11]3[CH:16]=[CH:15][C:14]([Cl:17])=[CH:13][CH:12]=3)[C:7]=2[CH:18]=1.[C-:19]#[N:20].[Na+]>CN(C)C=O>[Cl:17][C:14]1[CH:15]=[CH:16][C:11]([C:8]2[C:7]3[CH:18]=[C:3]([CH2:2][C:19]#[N:20])[CH:4]=[CH:5][C:6]=3[O:10][N:9]=2)=[CH:12][CH:13]=1

Participants

4

Reactant 2

HCID 8929Sodium CyanideHCID 12562677HCID 12562677, compound

Product 1

HCID 12562683HCID 12562683, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

A mixture of 5-bromomethyl-3-(4-chlorophenyl)-1,2-benzisoxazole (45 g.) and sodium cyanide (7.4 g.) in dry dimethylformamide (800 ml.) was heated on a steam bath for 3 hours. The mixture was filtered and the filtrate was evaporated to dryness, to give 3-(4-chlorophenyl)-1,2-benzisoxazol-5-ylacetonitrile (m.p. 118°C.).

Workup

  1. temperaturewas heated on a steam bath for 3 hours
  2. filtrationThe mixture was filtered
  3. customthe filtrate was evaporated to dryness

Sources & evidence

ORD record
ord-45323e7fc7274cd68c399307543b30fb
Source dataset
uspto-grants-1976_04
Patent number
US03951999

Reaction notes

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