反应详情

温度

105 °C

Aluminum chloride (267g) was added in portions over 30 minutes to a stirred solution of 4-ethylphenol (122.1g.) and 4-chloro-benzoyl chloride (140ml.) in dry 1,1,2,2-tetrachloroethane (800ml.). The mixture was heated at 105°C. for 22 hours with stirring, and on cooling a mixture of ice (600g) and concentrated hydrochloric acid was added slowly, A vigorous reaction occurred and some material was lost. The remaining material was separated and the aqueous fraction extracted twice with chloroform (200ml.), and the combined organic layers evaporated to a dark oil which was distilled in vacuo giving two main fractions: B (17.4g) 150°-160°C at 0.3mmHg; C (110.8g) 160°-168°C at 0.3mmHg. Both remained liquid on cooling.

1. temperatureon cooling
2. additionwas added slowly
3. customA vigorous reaction
4. customThe remaining material was separated
5. extractionthe aqueous fraction extracted twice with chloroform (200ml.)
6. customthe combined organic layers evaporated to a dark oil which
7. distillationwas distilled in vacuo
8. customgiving two main fractions
9. customB (17.4g) 150°-160°C
10. temperatureBoth remained liquid on cooling