Sodium Carbonate → HCID 12562671, compound

HRID 1606020Notes

Reaction equation

HRID 1606020 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8](=[N:17][OH:18])[C:9]2[CH:14]=[CH:13][C:12](C)=[CH:11][C:10]=2O)=[CH:4][CH:3]=1.[C:19](=O)([O-])[O-].[Na+].[Na+].O1C2C=CC=CC=2C=N1>O>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2[C:9]3[CH:10]=[C:11]([CH3:19])[CH:12]=[CH:13][C:14]=3[O:18][N:17]=2)=[CH:6][CH:7]=1

Participants

5

Reactant 3

HCID 10340Sodium CarbonateHCID 710731,2-BenzisoxazoleHCID 136353522HCID 136353522, compound

Product 1

HCID 12562671HCID 12562671, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

4'-Chloro-2-hydroxy-4-methylbenzophenone-oxime (0.2g) and anhydrous sodium carbonate (0.2g) were heated together under reflux in triglyome (5ml) for 30 minutes. On cooling, the mixture was poured into water (50ml.) and filtered. On standing a solid separated from the filtrate and was filtered, washed, dried and examined by NMR. The NMR spectrum was consistent with the preparation of the title compound (~30%). T.L.C. also confirmed the presence of the benzisoxazole.

Workup

  1. temperatureunder reflux in triglyome (5ml) for 30 minutes
  2. temperatureOn cooling
  3. filtrationfiltered
  4. customseparated from the filtrate
  5. filtrationwas filtered
  6. washwashed
  7. customdried
  8. customThe NMR spectrum was consistent with the preparation of the title compound (~30%)

Sources & evidence

ORD record
ord-99b0bbd030ae4f27b422414d507c06c6
Source dataset
uspto-grants-1976_04
Patent number
US03951999

Reaction notes

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