tert-Butoxy bis(dimethylamino)methane → HCID 53777236, compound

HRID 1606028Notes

Reaction equation

HRID 1606028 reaction equation
[N+:1]([C:4]1[N:8]([CH2:9][CH2:10][N:11]2[CH2:16][CH2:15][O:14][CH2:13][CH2:12]2)[C:7]([CH3:17])=[N:6][CH:5]=1)([O-:3])=[O:2].[CH3:18][N:19]([CH:21](N(C)C)OC(C)(C)C)[CH3:20]>CN(C)C=O>[N+:1]([C:4]1[N:8]([CH2:9][CH2:10][N:11]2[CH2:12][CH2:13][O:14][CH2:15][CH2:16]2)[C:7]([CH:17]=[CH:18][N:19]([CH3:21])[CH3:20])=[N:6][CH:5]=1)([O-:3])=[O:2]

Participants

4

Reactant 2

HCID 79885tert-Butoxy bis(dimethylamino)methaneHCID 428316HCID 428316, compound

Product 1

HCID 53777236HCID 53777236, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

2.4 g. (0.01 mole) of 5-nitro-2-methyl-1-(2-morpholinoethyl)-imidazole and 2.1 g. (0.012 mole) of bis-dimethylaminotert.-butoxymethane were heated in 9 ml. of dimethylformamide to 130° C. for 60 minutes. After removal of the solvent by evaporation, the residue was crystallized with isopropanol; m.p. 105°-106° C.

Workup

  1. customAfter removal of the solvent
  2. customby evaporation
  3. customthe residue was crystallized with isopropanol

Sources & evidence

ORD record
ord-25739910a5fa44d98663d3639da3f394
Source dataset
uspto-grants-1976_04
Patent number
US03952007

Reaction notes

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