3,5-diphenyl-4,5-dihydro-1H-pyrazole → 1H-Pyrazole, 3,5-diphenyl-

HRID 1606036Notes

Reaction equation

HRID 1606036 reaction equation
[C:1]1([C:7]2[CH2:11][CH:10]([C:12]3[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=3)[NH:9][N:8]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1>C(Cl)CCl.[Pd]>[C:1]1([C:7]2[CH:11]=[C:10]([C:12]3[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=3)[NH:9][N:8]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

Participants

4

Reactant 1

HCID 36838443,5-diphenyl-4,5-dihydro-1H-pyrazole

Product 1

HCID 708401H-Pyrazole, 3,5-diphenyl-Yield 79.3%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 111,2-DichloroethaneSolvent

Procedure

3,5-Diphenyl-2-pyrazoline (21.9 parts) is dissolved in ethylene dichloride (75 parts by volume). There is next added 5% palladium on carbon catalyst (4 parts containing 40% water) is added and the mixture is heated at reflux for 8 hours. There is obtained 3,5-diphenylpyrazole in a 79.3% yield whose melting point ranges from 196°C. to 200°C.

Workup

  1. additionis added
  2. temperaturethe mixture is heated
  3. temperatureat reflux for 8 hours

Sources & evidence

ORD record
ord-17f8933ac37a4cd09e61b29e373ec305
Source dataset
uspto-grants-1976_04
Patent number
US03952010

Reaction notes

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