1-Bromopropane → HCID 178460806, compound

3-Mercapto-1,2,4-triazole (20.2 g.) was added to a solution of 4.8 g. sodium in 150 ml. absolute ethanol. When dissolution was complete 24.6 g. propyl bromide was added. The stirred mixture was gradually heated to boiling under reflux, refluxed for 1 hour, cooled to room temperature and filtered. The filtrate was distilled to dryness under reduced pressure and the residue was dissolved in ether. The resulting solution was filtered, dried over anhydrous sodium sulphate and distilled under reduced pressure to give 3-propylthio-1,2,4-triazole, b.p. 143° - 144°C./1 mm. This product solidified, m.p. 53° - 56°C.

1. dissolutionWhen dissolution
2. temperatureThe stirred mixture was gradually heated
3. temperatureunder reflux
4. temperaturerefluxed for 1 hour
5. filtrationfiltered
6. distillationThe filtrate was distilled to dryness under reduced pressure
7. dissolutionthe residue was dissolved in ether
8. filtrationThe resulting solution was filtered
9. dry with materialdried over anhydrous sodium sulphate
10. distillationdistilled under reduced pressure

ORD record

ord-62a81ffa895b4f2f980efabeffa366a5

Source dataset

uspto-grants-1976_04

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US03952001