Water → HCID 21546014, compound

HRID 1606117Notes

Reaction equation

HRID 1606117 reaction equation
[CH2:1]1[C:4]2([CH2:22][O:21][CH2:20][CH2:19][NH:18][CH2:17][CH2:16][O:15][CH2:14][CH2:13][O:12][CH2:11][CH2:10][NH:9][CH2:8][CH2:7][O:6][CH2:5]2)[CH2:3][O:2]1.[OH2:23]>>[OH:2][CH2:3][C:4]1([CH2:1][OH:23])[CH2:22][O:21][CH2:20][CH2:19][NH:18][CH2:17][CH2:16][O:15][CH2:14][CH2:13][O:12][CH2:11][CH2:10][NH:9][CH2:8][CH2:7][O:6][CH2:5]1

Participants

3

Reactant 2

HCID 962WaterHCID 12212451HCID 12212451, compound

Product 1

HCID 21546014HCID 21546014, compound

Procedure

The oxetane ring in these macrocycles can be opened, by addition of water as well as of alcohols. For example, acid-catalysed hydrolysis of 2,6,12,15,21-pentaoxa-9,18-diazaspiro[3.18]docosane yields 12,12-bis(hydroxymethyl)-1,4,10,14-tetraoxa-7,17-diazacyclononadecane. ##EQU16##

Sources & evidence

ORD record
ord-4657552f46714ae0bf3713832eda6a1f
Source dataset
uspto-grants-1976_04
Patent number
US03952015

Reaction notes

Loading…