Sodium Hydroxide → HCID 54512127, compound

HRID 1606159Notes

Reaction equation

HRID 1606159 reaction equation
[Cl:1][C:2]1[CH:22]=[CH:21][C:5]([C:6]([C:8]2[N:12]([CH3:13])[C:11]([CH2:14][CH2:15][C:16]([O:18]CC)=[O:17])=[CH:10][CH:9]=2)=[O:7])=[CH:4][CH:3]=1.[OH-].[Na+]>C(O)C>[Cl:1][C:2]1[CH:22]=[CH:21][C:5]([C:6]([C:8]2[N:12]([CH3:13])[C:11]([CH2:14][CH2:15][C:16]([OH:18])=[O:17])=[CH:10][CH:9]=2)=[O:7])=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 21545860HCID 21545860, compound

Product 1

HCID 54512127HCID 54512127, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A suspension of 8.0 g. (0.025 mole) of ethyl 5-(p-chlorobenzoyl)-1-methylpyrrole-2-propionate in 15 ml. ethanol and 30 ml. 1N sodium hydroxide is refluxed for 1 hour. The ethanol is then evaporated and the remaining solution is poured into dilute hydrochloric acid. The resulting white precipitate is filtered off and purified by recrystallization from isopropyl alcohol, 5-(p-chlorobenzoyl)-1-methylpyrrole-2-propionic acid, m.p. 188°-191°C.

Workup

  1. additionA suspension of 8.0 g
  2. customThe ethanol is then evaporated
  3. additionthe remaining solution is poured into dilute hydrochloric acid
  4. filtrationThe resulting white precipitate is filtered off
  5. custompurified by recrystallization from isopropyl alcohol, 5-(p-chlorobenzoyl)-1-methylpyrrole-2-propionic acid, m.p. 188°-191°C.

Sources & evidence

ORD record
ord-8dbf896725034782bba4f921cef0fafd
Source dataset
uspto-grants-1976_04
Patent number
US03952012

Reaction notes

Loading…