Butyl bromide → HCID 68146765, compound

HRID 1606295Notes

Reaction equation

[CH3:1][C@:2]12[CH2:18][CH2:17][C@H:16]3[C@H:7]([CH2:8][CH2:9][C:10]4[CH:11]=[C:12]([OH:20])[CH:13]=[C:14]([OH:19])[C:15]=43)[C@@H:6]1[CH2:5][CH2:4][C@@H:3]2[OH:21].[CH2:22](Br)[CH2:23][CH2:24][CH3:25]>>[CH2:22]([O:19][C:14]1[C:15]2[C@@H:16]3[C@@H:7]([C@H:6]4[C@@:2]([CH2:18][CH2:17]3)([CH3:1])[C@@H:3]([OH:21])[CH2:4][CH2:5]4)[CH2:8][CH2:9][C:10]=2[CH:11]=[C:12]([O:20][CH2:1][CH2:2][CH2:3][CH3:4])[CH:13]=1)[CH2:23][CH2:24][CH3:25]

Participants

Reactant 2

HCID 8002Butyl bromide

HCID 68147230HCID 68147230, compound

Product 1

HCID 68146765HCID 68146765, compound

Procedure

Analogously to Example 12, 500 mg. of 8α -estra-1,3,5(10)-triene-1,3,17β-triol is reacted with 1.5 ml. of n-butyl bromide and worked up. Yield: 230 mg.

Sources & evidence

ORD record: ord-c7b5757548354f588d4206d8e96d0907
Source dataset: uspto-grants-1976_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US03951959

Reaction notes

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