Tris(hydroxymethyl)aminomethane → HCID 131710148, compound

HRID 1606334Notes

Reaction equation

HRID 1606334 reaction equation
[CH2:1]([C:4]1[C:13]2[O:12][C:11]([C:14]([OH:16])=[O:15])=[CH:10][C:9](=[O:17])[C:8]=2[C:7]([O:18][CH2:19][CH2:20][CH:21]([CH3:23])[CH3:22])=[CH:6][CH:5]=1)[CH:2]=[CH2:3].[OH:24][CH2:25][C:26]([CH2:30][OH:31])([CH2:28][OH:29])[NH2:27]>C(O)C>[OH2:12].[OH:24][CH2:25][C:26]([CH2:30][OH:31])([CH2:28][OH:29])[NH2:27].[CH2:1]([C:4]1[C:13]2[O:12][C:11]([C:14]([OH:16])=[O:15])=[CH:10][C:9](=[O:17])[C:8]=2[C:7]([O:18][CH2:19][CH2:20][CH:21]([CH3:23])[CH3:22])=[CH:6][CH:5]=1)[CH:2]=[CH2:3].[CH2:1]([C:4]1[C:13]2[O:12][C:11]([C:14]([OH:16])=[O:15])=[CH:10][C:9](=[O:17])[C:8]=2[C:7]([O:18][CH2:19][CH2:20][CH:21]([CH3:23])[CH3:22])=[CH:6][CH:5]=1)[CH:2]=[CH2:3].[OH:18][CH2:7][C:8]([NH2:27])([CH2:9][OH:17])[CH2:13][OH:12]

Participants

4

Reactant 2

HCID 6503Tris(hydroxymethyl)aminomethaneHCID 126440HCID 126440, compound

Product 1

HCID 131710148HCID 131710148, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A solution of 5.66 parts of 8-allyl-5-(3-methyl-n-butoxy)-4-oxo-4H-1-benzopyran-2-carboxylic acid and 2.16 parts of tris-(hydroxymethyl)methylamine in 50 parts of ethanol was refluxed for 2 hours. The solution was filtered and evaporated to an oil which was triturated with ether to give 7.1 parts of 8-allyl-5-(3-methyl-n-butoxy)-4-oxo-4H-1-benzopyran-2-carboxylic acid tris-(hydroxymethyl)methylamine salt hemihydrate as a pale yellow solid.

Workup

  1. filtrationThe solution was filtered
  2. customevaporated to an oil which
  3. customwas triturated with ether

Sources & evidence

ORD record
ord-e8f80f1c5f1841a6ace25d42f5a092d6
Source dataset
uspto-grants-1976_04
Patent number
US03952104

Reaction notes

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