Morpholine → HCID 22789169, compound

HRID 1606355Notes

Reaction equation

HRID 1606355 reaction equation
Cl[CH2:2][CH2:3][O:4][C@H:5]1[CH2:24][C@@:23]2([CH3:25])[C@@H:8]([CH2:9][CH2:10][C@@H:11]3[C@@H:22]2[C:21](=[O:26])[CH2:20][C@@:19]2([CH3:27])[C@H:12]3[CH2:13][CH2:14][C@@H:15]2[C:16](=[O:18])[CH3:17])[CH2:7][C@@H:6]1[OH:28].[NH:29]1[CH2:34][CH2:33][O:32][CH2:31][CH2:30]1>>[OH:28][C@@H:6]1[C@@H:5]([O:4][CH2:3][CH2:2][N:29]2[CH2:34][CH2:33][O:32][CH2:31][CH2:30]2)[CH2:24][C@@:23]2([CH3:25])[C@@H:8]([CH2:9][CH2:10][C@@H:11]3[C@@H:22]2[C:21](=[O:26])[CH2:20][C@@:19]2([CH3:27])[C@H:12]3[CH2:13][CH2:14][C@@H:15]2[C:16](=[O:18])[CH3:17])[CH2:7]1

Participants

3

Reactant 2

HCID 8083MorpholineHCID 22789153HCID 22789153, compound

Product 1

HCID 22789169HCID 22789169, compound

Procedure

2β(2'-Chloroethoxy)-3α-hydroxy-5α-pregnane-11,20-dione (100 mg.) was dissolved in morpholine (10 ml.) and the solution heated on a steam-bath for 24 hours, complete reaction occurring. The morpholine was evaporated off in vacuo and the orange oil obtained purified by preparative TLC in ethyl acetate to give the title compound (40 mg.) as a pale yellow oil.

Workup

  1. temperaturethe solution heated on a steam-bath for 24 hours
  2. customcomplete reaction
  3. customThe morpholine was evaporated off in vacuo
  4. customthe orange oil obtained
  5. custompurified by preparative TLC in ethyl acetate

Sources & evidence

ORD record
ord-f89e9cca46ff42539ebd9d14fc054233
Source dataset
uspto-grants-1976_04
Patent number
US03952031

Reaction notes

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