反应详情

The first step of the process comprises reacting a spiro (cyclohexane-1,2'-indan)-4-one (II) or a 3',4'-dihydrospiro[cyclohexane-1,2'(1'H)-naphthalen]-4-one (II) with an acid addition salt of hydroxylamine and an alkali metal hydroxide such as sodium hydroxide at reflux temperature for from about 4 to about 8 hours to obtain the corresponding spiro(cyclohexane-1,2'-indan)-4-one oxime (III) or the corresponding 3',4'-dihydrospiro[cyclohexane-1,2'-(1'H)naphthalen]-4-one oxime (III), respectively.