Dichloromethane → 1175-97-9

HRID 1606423Notes

Reaction equation

HRID 1606423 reaction equation
Cl[CH2:2]Cl.[CH3:4][C:5]1([CH3:27])[S:9][C@@H:8]2[C@H:10]([NH:13][C:14]([C@H:16]([NH2:23])[C:17]3[CH:18]=[CH:19][CH:20]=[CH:21][CH:22]=3)=[O:15])[C:11](=[O:12])[N:7]2[C@H:6]1[C:24]([OH:26])=[O:25].O.O.O.S([O-])([O-])(=O)=O.[Mg+2]>C(N(CC)CC)C>[CH3:4][C:5]1([CH3:27])[S:9][C@@H:8]2[C@H:10]([NH:13][C:14]([C@H:16]([NH2:23])[C:17]3[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=3)=[O:15])[C:11](=[O:12])[N:7]2[C@H:6]1[C:24]([OH:26])=[O:25].[CH2:11]([N:7]([CH2:6][CH3:24])[CH2:8][CH3:2])[CH3:10]

Participants

5

Reactant 3

HCID 6344DichloromethaneHCID 23565Ampicillin TrihydrateHCID 24083Sulfuric acid magnesium salt (1:1)

Product 1

HCID 129189941175-97-9

Reagents, catalysts & solvents 1

HCID 8471TriethylamineSolvent

Procedure

To 14 ml. of dichloromethane were added 806 mg. of ampicillin trihydrate, 600 mg. of magnesium sulfate, and 0.42 ml. of triethylamine and after stirring the mixture for about 1 hour at room temperature, magnesium sulfate was filtered off to provide a dichloromethane solution of ampicillin triethylamine salt.

Workup

  1. filtrationmagnesium sulfate was filtered off

Sources & evidence

ORD record
ord-0a4a0ff74e6f433db547a5ffd3334b16
Source dataset
uspto-grants-1976_04
Patent number
US03953428

Reaction notes

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