Dichloromethane → 1175-97-9

HRID 1606433Notes

Reaction equation

HRID 1606433 reaction equation
[CH3:1][C:2]1([CH3:24])[S:6][C@@H:5]2[C@H:7]([NH:10][C:11]([C@H:13]([NH2:20])[C:14]3[CH:15]=[CH:16][CH:17]=[CH:18][CH:19]=3)=[O:12])[C:8](=[O:9])[N:4]2[C@H:3]1[C:21]([OH:23])=[O:22].O.O.O.S([O-])([O-])(=O)=O.[Mg+2].Cl[CH2:35]Cl>C(N(CC)CC)C>[CH3:1][C:2]1([CH3:24])[S:6][C@@H:5]2[C@H:7]([NH:10][C:11]([C@H:13]([NH2:20])[C:14]3[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=3)=[O:12])[C:8](=[O:9])[N:4]2[C@H:3]1[C:21]([OH:23])=[O:22].[CH2:8]([N:4]([CH2:3][CH3:21])[CH2:5][CH3:35])[CH3:7]

Participants

5

Reactant 3

HCID 6344DichloromethaneHCID 23565Ampicillin TrihydrateHCID 24083Sulfuric acid magnesium salt (1:1)

Product 1

HCID 129189941175-97-9

Reagents, catalysts & solvents 1

HCID 8471TriethylamineSolvent

Procedure

after stirring a mixture of 8.0 g. of ampicillin trihydrate, 6 g. of anhydrous magnesium sulfate, 150 ml. of dichloromethane, and 4.2 ml. of triethylamine for 1 hour at room temperature, the magnesium sulfate was filtered away to provide dichloromethane solution of ampicillin triethylamine salt.

Workup

  1. additiona mixture of 8.0 g
  2. filtrationthe magnesium sulfate was filtered away

Sources & evidence

ORD record
ord-1797ea97c87348e2931d13ba71ba9835
Source dataset
uspto-grants-1976_04
Patent number
US03953428

Reaction notes

Loading…