1,1-Dichloroethane → 1175-97-9

HRID 1606434Notes

Reaction equation

HRID 1606434 reaction equation
[CH3:1][C:2]1([CH3:24])[S:6][C@@H:5]2[C@H:7]([NH:10][C:11]([C@H:13]([NH2:20])[C:14]3[CH:15]=[CH:16][CH:17]=[CH:18][CH:19]=3)=[O:12])[C:8](=[O:9])[N:4]2[C@H:3]1[C:21]([OH:23])=[O:22].O.O.O.S([O-])([O-])(=O)=O.[Mg+2].Cl[CH:35](Cl)[CH3:36]>C(N(CC)CC)C>[CH3:1][C:2]1([CH3:24])[S:6][C@@H:5]2[C@H:7]([NH:10][C:11]([C@H:13]([NH2:20])[C:14]3[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=3)=[O:12])[C:8](=[O:9])[N:4]2[C@H:3]1[C:21]([OH:23])=[O:22].[CH2:3]([N:4]([CH2:35][CH3:36])[CH2:5][CH3:7])[CH3:2]

Participants

5

Reactant 3

HCID 63651,1-DichloroethaneHCID 23565Ampicillin TrihydrateHCID 24083Sulfuric acid magnesium salt (1:1)

Product 1

HCID 129189941175-97-9

Reagents, catalysts & solvents 1

HCID 8471TriethylamineSolvent

Procedure

after stirring a mixture of 4.0 g. of ampicillin trihydrate, 3.0 g. of magnesium sulfate, 2.1 ml. of triethylamine, and 60 ml. of dichloroethane for 1 hour at room temperature, the magnesium sulfate was filtered off to provide a dichloromethane solution of ampicillin triethylamine salt.

Workup

  1. additiona mixture of 4.0 g
  2. filtrationthe magnesium sulfate was filtered off

Sources & evidence

ORD record
ord-ab93c3b4d7f8416ab76ac13d004b8e67
Source dataset
uspto-grants-1976_04
Patent number
US03953428

Reaction notes

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