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HRID1606478

反应详情

EQUATION

反应方程式

HRID 1606478 的结构方程式

REACTANTS

反应物

3
结构：O
HCID962

Water

H2O

结构：CC(=O)OC(C)=O
HCID7918

Acetic anhydride

C4H6O3

结构：CC(=O)[C@H]1CC[C@H]2[C@@H]3CC[C@H]4C[C@H](O)[C@@H](Br)C[C@]4(C)[C@H]3C(=O)C[C@]12C
HCID86733291

未命名化合物

PRODUCTS

生成物

1
结构：CC(=O)O[C@H]1C[C@@H]2CC[C@H]3[C@@H]4CC[C@H](C(C)=O)[C@@]4(C)CC(=O)[C@@H]3[C@@]2(C)C[C@@H]1Br
HCID86733290

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

1
结构：c1ccncc1
溶剂HCID1049

Pyridine

C5H5N

PROCEDURE

实验过程

2β-Bromo-3α-hydroxy-5α-pregnane-11,20-dione (750 mg.) in pyridine (2 ml.) was treated with acetic anhydride (1 ml.) and the mixture was allowed to stand at room temperature overnight. It was then poured into water to give a white solid (720 mg.) which was recrystallised from methanol to give 3α-acetoxy-2β-bromo-5α-pregnane-11,20-dione (471 mg.) as white crystals, m.p. 154°-156°, [α]D + 128.5°.

WORKUP

后处理

  1. customto give a white solid (720 mg.) which
  2. customwas recrystallised from methanol