Water → HCID 86733290, compound

Participants

Reaction Steps

2β-Bromo-3α-hydroxy-5α-pregnane-11,20-dione (750 mg.) in pyridine (2 ml.) was treated with acetic anhydride (1 ml.) and the mixture was allowed to stand at room temperature overnight. It was then poured into water to give a white solid (720 mg.) which was recrystallised from methanol to give 3α-acetoxy-2β-bromo-5α-pregnane-11,20-dione (471 mg.) as white crystals, m.p. 154°-156°, [α]D + 128.5°.

Provenance & Evidence