反应详情

A mixture of 20,20-ethylenedioxy-2-hydroxymethylene-5α-pregnane-3,11-dione (6 g.), palladium-on-charcoal (10%, 2.5 g.) and ethyl acetate (250 ml.) was shaken under hydrogen for 51/2 hr. The mixture was then filtered through Kieselguhr and the filtrate was evaporated to dryness (6.1 g.) in vacuo. A portion of the residue (3 g.) was subjected to preparative t.l.c. The less polar fraction (0.59 g.) was crystallised from methanol to give title compound (0.35 g.), m.p. 168°-169°.

1. filtrationThe mixture was then filtered through Kieselguhr
2. customthe filtrate was evaporated to dryness (6.1 g.) in vacuo
3. customThe less polar fraction (0.59 g.) was crystallised from methanol