HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 16065Generated: October 25, 2026
Methylamine → 5-{6-Amino-2-[3-(4-methylcarbamoyl-cyclohexyl)-prop-1-ynyl]purin-9-yl}-3,4-dihydroxytetrahydrofuran-2-carboxylic acid ethylamide
https://huagongshe.com/reaction/16065
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Methylamine | HCID 6329 | — |
| Reactant | Apadenoson | HCID 9805430 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 5-{6-Amino-2-[3-(4-methylcarbamoyl-cyclohexyl)-prop-1-ynyl]purin-9-yl}-3,4-dihydroxytetrahydrofuran-2-carboxylic acid ethylamide | HCID 67280562 | 48% |
Reaction Steps
To a sealed tube containing 10 mL 2.0 M methylamine in methanol was added 16.5 mg (0.03 mmol) of ATL146e. The flask was sealed and allowed to stir at 70° C. for 120 hours. The vessel was cooled to 0° C., opened, and the solvent was removed in vacuo to yield 8.0 mg (48%) of JR3065 as a white solid after the residue was purified by RP-HPLC. 1H NMR (CD3OD-d4) δ. 13C NMR (CD3OD-d4) δ. APCI m/z (rel intensity) 486.3 (MH+, 100), 313.4 (35).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US07737127B2 |
|---|
| Source dataset | uspto-grants-2010_06 |
|---|
| ORD ID | ord-725c15caf0dc4b3d8c11ea508702542d |
|---|
| Source note | uspto-grants-2010_06 |
|---|
