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HRID16065

反应详情

EQUATION

反应方程式

HRID 16065 的结构方程式

REACTANTS

反应物

2
结构：CN
HCID6329

Methylamine

CH5N

结构：CCNC(=O)[C@H]1O[C@@H](n2cnc3c(N)nc(C#CCC4CCC(C(=O)OC)CC4)nc32)[C@H](O)[C@@H]1O
HCID9805430

未命名化合物

PRODUCTS

生成物

1
结构：CCNC(=O)C1OC(n2cnc3c(N)nc(C#CCC4CCC(C(=O)NC)CC4)nc32)C(O)C1O
HCID67280562

未命名化合物

收率 48%

AUXILIARIES

试剂、催化剂与溶剂

1
结构：CO
溶剂HCID887

Methanol

CH4O

CONDITIONS

反应条件

温度
70 °C

PROCEDURE

实验过程

To a sealed tube containing 10 mL 2.0 M methylamine in methanol was added 16.5 mg (0.03 mmol) of ATL146e. The flask was sealed and allowed to stir at 70° C. for 120 hours. The vessel was cooled to 0° C., opened, and the solvent was removed in vacuo to yield 8.0 mg (48%) of JR3065 as a white solid after the residue was purified by RP-HPLC. 1H NMR (CD3OD-d4) δ. 13C NMR (CD3OD-d4) δ. APCI m/z (rel intensity) 486.3 (MH+, 100), 313.4 (35).

WORKUP

后处理

  1. customThe flask was sealed
  2. temperatureThe vessel was cooled to 0° C.
  3. customthe solvent was removed in vacuo