Hydrochloric Acid → HCID 21543498, compound

HRID 1606507Notes

Reaction equation

HRID 1606507 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[N:7]([C:11]1[CH:16]=[CH:15][C:14]([F:17])=[CH:13][CH:12]=1)[CH:6]=[C:5]2[CH2:18]C(C1OCCO1)C.Cl.[CH2:27]([OH:29])[CH3:28]>>[Cl:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[N:7]([C:11]1[CH:16]=[CH:15][C:14]([F:17])=[CH:13][CH:12]=1)[CH:6]=[C:5]2[CH2:18][C:27](=[O:29])[CH3:28]

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 702EthanolHCID 21543499HCID 21543499, compound

Product 1

HCID 21543498HCID 21543498, compound

Procedure

A mixture of 14g of 5-chloro-3-[2(1,3-dioxolan-2-yl)propyl]-1-(4-fluorophenyl)indole, 112 ml of 96% ethyl alcohol, and 12 ml of 6N hydrochloric acid are heated to reflux for 30 minutes. The reaction mixture is concentrated then dissolved in water and extracted with ether. The organic phase is washed in water, dried, concentrated and then distilled.

Workup

  1. temperatureare heated
  2. temperatureto reflux for 30 minutes
  3. concentrationThe reaction mixture is concentrated
  4. dissolutionthen dissolved in water
  5. extractionextracted with ether
  6. washThe organic phase is washed in water
  7. customdried
  8. concentrationconcentrated
  9. distillationdistilled

Sources & evidence

ORD record
ord-1ad902a9a1b043acb89abe5ffaa74d42
Source dataset
uspto-grants-1976_04
Patent number
US03953442

Reaction notes

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