反应详情

To 2-hydrazinoquinoline (15.9 grams; 0.1 mole) in 70 milliliters xylene was added 13.0 grams (0.11 mole) methyl orthoacetate (13.0 grams; 0.11 mole). The stirred solution was refluxed for four hours, during which the methanol that distilled from the reaction was collected. The reaction mixture was cooled overnight, and filtered to separate the desired 1-methyl-s-triazolo(4,3-a)quinoline product. It was recrystallized from 1-butanol, yield, 9.0 grams, m.p., 166°-7°C.

1. distillationthat distilled from the reaction
2. customwas collected
3. temperatureThe reaction mixture was cooled overnight
4. filtrationfiltered
5. customto separate the desired 1-methyl-s-triazolo(4,3-a)quinoline product
6. customIt was recrystallized from 1-butanol
7. customyield
8. customm.p., 166°-7°C.